Which is stronger clindamycin or amoxicillin

Clindamycin can alter the bacterial composition of the colon and cause an overgrowth of the Clostridium difficile C. This bacterium produces toxins that can cause C.

CDAD is a severe and life-threatening infection. If a person develops CDAD while taking clindamycin, the doctor will immediately stop the antibiotic.

People using clindamycin solution or lotion for acne may report skin-related side effects, including:. For example, when an individual uses Clindagel for acne, the most common side effects are itchiness and skin peeling. People rarely experience diarrhea or colitis after using clindamycin topically. However, some people have reported abdominal disturbances.

Clindamycin suppositories and vaginal cream may cause the same side effects as the oral or injectable forms. People with a history of pseudomembranous or ulcerative colitis should not take clindamycin. These two conditions cause severe inflammation of the lining of the intestine. Doctors should only prescribe clindamycin to people who have bacterial infections.

This helps reduce the resistance that bacteria can develop to clindamycin. Learn more about antibiotic resistance here.

Doctors should prescribe clindamycin with caution to people taking neuromuscular blocking agents. These drugs play a role in certain medical procedures and operations. When people take oral forms of clindamycin, the liver enzyme CYP3A4 breaks it down in the body.

Stimulating the function of this enzyme can cause a decrease in levels of clindamycin. If something inhibits CYP3A4, clindamycin levels may increase in the blood. Certain drugs can affect the functioning of CYP3A4. When people are taking CYP3A4 stimulants along with clindamycin, doctors must follow up and make sure that the antibiotic is working. If a person is taking an inhibitor of CYP3A4 with clindamycin, the increased levels of the antibiotic may cause side effects.

Doctors should monitor any increase in adverse effects. Lincomycin is only available in an injectable solution and is prescribed by doctors for serious infections. Clindamycin is an effective antibiotic for a variety of serious infections. People also use clindamycin for treating acne. There are many possible side effects of clindamycin, and doctors should weigh the benefits and risks before prescribing this antibiotic.

Subjects recruited in the study were South East Asian in origin with similar age and sex distribution across both treatment arms. Periapical abscess was the predominant odontogenic infection across both arms The percentage of subjects achieving clinical success using the primary analysis population was The treatment difference between the treatment arms was 1. Similar results were also noted for swelling Table 3. Organisms isolated in both the treatment arms were similar and predominantly viridans streptococci group including Streptococcus oralis , Streptococcus mitis , and Streptococcus parasanguinis , Enterobacter spp.

CLSI breakpoints are not uniformly available for all isolates for both study drugs which posed a challenge in providing meaningful interpretation of susceptibility data. Generally the incidence of TEAEs was similar between treatment arms, except for diarrhoea and headache which were reported in slightly more patients in the clindamycin arm. Most AEs were of mild to moderate intensity.

The most frequently reported drug related TEAEs were gastrointestinal disorders including abdominal discomfort, diarrhoea, nausea and vomiting, abnormal LFTs, increased appetite, somnolence, dizziness, and headache. Most of the related TEAEs were mild to moderate in intensity except for six events of severe intensity. All events had resolved by the end of the study except hypersomnia. The probable reason for the ongoing AEs could be the short duration of the study 7 to 8 days and the lack of a planned follow-up visit after study treatment.

No subjects in the study showed shift in ALT and AST from normal at baseline with respect to local laboratory reference range to PCC range as defined in statistical analysis section at end of the study whereas three subjects each in both the study arms showed shift in total bilirubin to PCC range at the end of the study.

However, since these subjects only had increased bilirubin with no increase in ALT or AST, these were not of clinical concern. No events of SAE or death were reported in the study.

The primary treatment in acute odontogenic infections is surgical drainage while antibiotics are an adjunct in patients showing signs of systemic involvement [ 12 ].

The polymicrobial component of odontogenic infection necessitates the use of antibiotics that are active against both aerobic and anaerobic bacteria and therefore are recommended [ 4 ].

A higher percentage of pain and swelling reduction Safety of the subjects, assessed throughout the study, showed that the overall incidences of TEAEs were similar across both the treatment arms. These were mainly events such as abdominal discomfort, diarrhoea, and raised liver enzymes. Diarrhoea was seen in 8. In the current study, a total of 34 subjects However, most of these events were of mild to moderate intensity and none of the subjects were considered to have any LFT values that were of clinical concern.

Pseudomembranous colitis is a rare but serious side effect of both clindamycin and amoxicillin-clavulanic acid. However, literature evidence suggests that the incidence is particularly low when these antibiotics are given in outpatient care settings 6. In dental infections there is not much difference in the incidence of C. In the current study there were no cases of pseudomembranous colitis with either of the study drugs. There were no SAEs or deaths reported in this study.

One of the main limitations of the study was the use of an outcome measure based on a subjective score VAS score to assess pain and swelling to derive the composite clinical outcome.

Another limitation was not having a planned follow-up visit for the subjects after the end of the study visits. As a result, ongoing AEs typically key laboratory parameters such as liver enzymes could not be followed until resolution; however, most were mild and transient in nature. Mohd Asari, and Tran Xuan Thong declare no conflict of interests regarding the publication of this paper.

This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Article of the Year Award: Outstanding research contributions of , as selected by our Chief Editors. Read the winning articles. Journal overview. Special Issues. Academic Editor: Yoshitaka Hara.

Received 27 Apr Accepted 06 Jul Published 02 Aug Abstract Background. Introduction Odontogenic infections are one of the most prevalent diseases worldwide and the principal reason for seeking dental care.

Methods 2. Figure 1. Study schema. Note: the study had a 1-day screening period Day 1 to Day 0 during which eligibility was assessed and laboratory tests were performed. Randomisation occurred within 24 hours of screening at baseline Day 0.

Table 1. Tooth infections often require antibiotic treatment. Read on to learn more about taking clindamycin for a tooth infection, including how long it takes to start working. Penicillin antibiotics, such as penicillin or amoxicillin, are most commonly used to treat tooth infections.

This is important when it comes to tooth infections, which often involve several types of bacteria. There may be one or two capsules in a dose. Be sure to carefully follow the instructions provided with your prescription. You can take clindamycin either before or after eating. Some people experience throat irritation when taking clindamycin, but following the dose with a full glass of water can help you avoid this.

Make sure you take the full course of antibiotics as prescribed by your doctor, even if you start to feel better before finishing them.

Otherwise, you may not kill all of the bacteria, which can lead to recurring infections and antibiotic resistance. Allergic reactions to clindamycin are rare. If you develop any kind of rash while taking clindamycin, contact your healthcare provider — this may be a sign of a drug allergy. Anaphylaxis is a medical emergency that requires immediate treatment. You can help to reduce nausea and vomiting by sticking with a simple, bland diet while taking clindamycin.

Avoid spicy or rich foods that may irritate your stomach. Taking a probiotic , which may help to replenish beneficial bacteria in your gut, may also minimize side effects. If you experience frequent, watery diarrhea while taking clindamycin, contact your healthcare provider before taking another dose. In rare cases, taking clindamycin can increase your risk of infection with Clostridium difficile. This can cause the bacteria to grow out of control, which can potentially lead to a serious infection.